Title: How have we eliminated implant infection ? In over 30,000 patients and still counting ?

Implant infection is rising with the U.S. Centers for Disease Control predicting one person every three seconds will die from a bacteria infection by 2050. Nanomedicine is the use of nanomaterials to improve disease prevention, detection, and treatment which has resulted in hundr [....] » Read More

Title: Surgery: Sepsis in severe acute pancreatitis

Severe acute pancreatitis (SAP) has many similarities with sepsis syndrome and septic shock. The hemodynamic features are virtually indistinguishable in each of these conditions. Septic complications of SAP are usually late manifestations, although sterile pancreatic necrosis is [....] » Read More

Title: Toxoplasmosis in immunocompetent children

Toxoplasmosis is a zoonotic infection caused by the parasite Toxoplasma gondii. T. gondii is found worldwide, with the possible exception of Antarctica. The parasite is capable of invading and replicating within almost all mammalian cells. It is estimated that approximately 25 to [....] » Read More

Title: Hepatitis D Virus Update

Hepatitis D virus (HDV), also known as hepatitis delta virus, is a defective virus that requires hepatitis B virus (HBV) to multiply and cause disease in humans. HDV seroprevalence is estimated at 0.16% in the general population and 4.5% (11-13 million) in HBV carriers. The pr [....] » Read More

Title: Decidual natural killer cells dysfunction is caused by IDO downregulation in dMDSCs with Toxoplasma gondii infection

Background: Myeloid-derived suppressor cells (MDSCs) play a crucial role in maintaining maternal-fetal tolerance by expressing some immune-suppressive molecules, such as indoleamine 2,3-dioxygenase (IDO). Toxoplasma gondii (T. gondii) infection can break the immune microenvironme [....] » Read More

Title: Development of SYN023 Anti-Rabies mAb Cocktail

SYN023 is a mixture of two anti-rabies humanized monoclonal IgG1κ antibodies which bind to distinct and non-overlapping antigenic sites on the rabies virus glycoprotein.  A Phase 2b and a Phase 3 randomized double-blinded trials were conducted to demonstrate the safety [....] » Read More

Title: Rotameric shift in dihedral angels of side chains of certain amino acids in Hcp1 nanotube of type VI secretion system in Acinetobacter baumannii cause extrusion of cytotoxins

The primary objective of this study is to understand how a potential toxic effector of the type VI secretion system (T6SS) in Acinetobacter baumannii triggers the contraction of the Hemolysin-coregulated protein-1 (Hcp1) tail/tube and its propulsion to T6SS tip via the applicatio [....] » Read More

Title: What do HIV stigma index studies say in Iran?

HIV-related stigma and discrimination are very common, especially in the developing countries. Stigma is also one of the most significant barriers to adherence to long-term treatment that prevents patients from taking antiretroviral therapy (ART). Two projects have been conducted [....] » Read More

Title: Mechanisms of G-gene heterogeneities and a new method of genotyping of human metapneumovirus

Human metapneumovirus (HMPV) is similar to AMPV and HRSV single-stranded RNA viruses. Controversy of HMPV G-gene heterogeneities due to duplication, deletion, recombination and termination codon mutation (TCM) complicated genotyping of a HMPV virus since 2015. Analysis of G-prote [....] » Read More